@article{APS6578,
author = {Zhi-Qiang Jiang and Gui-Ming Sun and Yuan-Ming Ma},
title = {Artificial reconstituted pulmonary surfactant in prevention and treatment of respiratory distress syndrome in neonates},
journal = {Acta Pharmacologica Sinica},
volume = {18},
number = {2},
year = {2016},
keywords = {},
abstract = {AIM: To test an artificial reconstituted pulmonary surfactant (APS) for
prevention and treatment of respiratory distress syndrome (RDS).
METHODS: A membrane-formed method combined with supersonic dispersing was used to
prepare APS. A pulsating bubble surface tension measurement was established to
compare surface properties of APS with natural pulmonary surfactant (NPS). A
preliminary clinical trial was made for prevention and treatment of RDS.
RESULTS: The APS reduced surface tension from 44.0 mN/m to < 1.0 mN/m in vitro.
The changes of APS lipid contents were < 5% of labeled content at 37 degrees C.
Clinical trial showed that the APS prevented RDS in 20/20 and cured RDS in 2/2
premature neonates.
CONCLUSION: The APS had good surface properties similar to NPS.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6578}
}