@article{APS6567,
author = {Hui-Juan Hu and De-Zai Dai and Yong-Ming Shen},
title = {Histamine aggravated levothyroxine-induced cardiomyopathy in guinea pigs},
journal = {Acta Pharmacologica Sinica},
volume = {18},
number = {2},
year = {2016},
keywords = {},
abstract = {AIM: To study effects of histamine on cardiomyopathy.
METHODS: Cardiomyopathy model was developed in guinea pig by i.p. levothyroxine
0.5 mg.kg-1.d-1 for 10 d. Langendroff's hearts were perfused. ECG and contractile
force were recorded. Histamine (5 micrograms) was given by intra-aortic
injection. Histamine content of coronary venous effluent was determined
fluorometrically.
RESULTS: Attack of histamine on cardiomyopathy was severer than that in normal
hearts. Tachycardia was more prominent; atrioventricular conduction block
occurred earlier; decrease in coronary flow was more marked. Uptakes of histamine
were 37% in the model and 19% in the normal hearts (P < 0.01).
CONCLUSION: Histamine aggravated levothyroxine-cardiomyopathy.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6567}
}