TY - JOUR AU - You Yu-Hong AU - Huang Zi-Qiang AU - Li Chang-Chun PY - 2016 TI - Effects of melitten on isolated rat atrium JF - Acta Pharmacologica Sinica; Vol 18, No 1 (January 1997): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - AIM :To8tudYtheefectsofmeliten(Md)onrat heart. METHODS: The isolated rat atria were adopted. Before and after giving M el, t}le heart rate,contraction ofatrium,post-restomataretion and staircase were m easured. RESULTS: Verapamil(V日 ) 0.1 ~tmol·L-1 was found to inhibit heart rate in the right atria of rats increased by M el20.0 mg·L~ . Inldtatriaofrats,the D0s£-rest o~ntracfon wa3 jnKbited na d typical positive staircase was markedly at tenuated by Md 2.5 m g ‘L~ . Md possessed negative inotropie elfecur on both t}le left na d right atria of rats. CONCLUSION: Md posesed negative inotropie and positive chronotropicactionson rat heart. UR - http://www.chinaphar.com/article/view/6542