TY - JOUR AU - Li Ji AU - Ge Rui-Chang AU - Zheng Rong-Liang AU - Liu Zi-Min AU - Jia Zhong-Jian PY - 2016 TI - Antioxidative and chelating activities of phenylpropanoid glycosides from Pedicularis striata JF - Acta Pharmacologica Sinica; Vol 18, No 1 (January 1997): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - AIM: To study the antioxidative and iron chelating activities of phenylpropanoid glycosides (PPG) isolated from a Chinese herb Pedicularis striata. METHODS: Antioxidative effects of PPG on lipid peroxidation induced by FeSO4-edetic acid in linoleic acid were measured by thiobarbituric acid method. Chelating activities of PPG for Fe2+ were tested by differential spectrum method. RESULTS: The reaction rates (A532.min-1) of lipid peroxidation were 0.0046 in the control, 0.0021 in verbascoside group, and 0.0008 in isoverbascoside group. The chelating activity of isoverbascoside was 2-fold stronger than that of verbascoside. Permethyl verbascoside showed neither antioxidative nor chelating activities. CONCLUSION: The inhibitory effects of PPG with phenolic hydroxy groups on lipid peroxidation are owing to their chelating properties. Under physiological condition PPG-Fe2+ chelates are sufficiently stable. Thus PPG are able to inhibit the Fe(2+)-dependent lipid peroxidation in vivo through chelating Fe2+ and exhibit their therapeutic potential by the same mechanism in vitro. UR - http://www.chinaphar.com/article/view/6539