@article{APS6528,
author = {Ya-Ping Liu and Jie Liu},
title = {Effect of alpha-hederin on hepatic detoxifying systems in mice},
journal = {Acta Pharmacologica Sinica},
volume = {18},
number = {1},
year = {2016},
keywords = {},
abstract = {AIM: To examine whether alpha-hederin (Hed) modulates hepatic detoxifying systems
as a means of hepatoprotection.
METHODS: Mice were injected Hed 10 and 30 mumol.kg-1 sc for 3 d, and liver
cytosols were prepared 24 h after the last dose to study antioxidant enzymes and
nonenzymatic defense components.
RESULTS: Hed increased liver glutathione (GSH) content (20%), but had no effect
on GSH peroxidase, GSH reductase, and GSH S-transferase. The activities of
superoxide dismutase and quinone reductase were unaffected by Hed treatment. At
the high dose of Hed, catalase activity was decreased by 20%. Hepatic content of
metallothionein was dramatically increased (50-fold), along with elevations of
hepatic Zn and Cu concentrations (25%-80%). Hed also increased ascorbic acid
concentration (20%), but no effect on alpha-tocopherol in liver.
CONCLUSION: Hed enhanced some nonenzymatic antioxidant components in liver, which
play a partial role in Hed protection against hepatotoxicity produced by some
chemicals.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6528}
}