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Effect of alpha-hederin on hepatic detoxifying systems in mice

	author = {Ya-Ping Liu and Jie Liu},
	title = {Effect of alpha-hederin on hepatic detoxifying systems in mice},
	journal = {Acta Pharmacologica Sinica},
	volume = {18},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {AIM: To examine whether alpha-hederin (Hed) modulates hepatic detoxifying systems
as a means of hepatoprotection.
METHODS: Mice were injected Hed 10 and 30 sc for 3 d, and liver
cytosols were prepared 24 h after the last dose to study antioxidant enzymes and 
nonenzymatic defense components.
RESULTS: Hed increased liver glutathione (GSH) content (20%), but had no effect
on GSH peroxidase, GSH reductase, and GSH S-transferase. The activities of
superoxide dismutase and quinone reductase were unaffected by Hed treatment. At
the high dose of Hed, catalase activity was decreased by 20%. Hepatic content of 
metallothionein was dramatically increased (50-fold), along with elevations of
hepatic Zn and Cu concentrations (25%-80%). Hed also increased ascorbic acid
concentration (20%), but no effect on alpha-tocopherol in liver.
CONCLUSION: Hed enhanced some nonenzymatic antioxidant components in liver, which
play a partial role in Hed protection against hepatotoxicity produced by some
	issn = {1745-7254},	url = {}