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Effects of m-nisoldipine on arterial baroreflex sensitivity in anesthetized rats

   
@article{APS6472,
	author = {Ya-lan Zhang and Shao-xuan Fu and Yun-shan Li},
	title = {Effects of m-nisoldipine on arterial baroreflex sensitivity in anesthetized rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {15},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {Baroreflex sensitivity (BRS) in anesthetized rats was measured as the slope of the regression line of the concomitant maximal change in heart rate (delta R-R) and blood pressure (delta BP) induced by bolus i.v. phenylephrine or sodium nitroprusside, m-nisoldipine (m-Nis) i.v. 5, 10, 20 micrograms.kg-1 depressed the BRS (2.6 +/- 0.2, 2.4 +/- 0.3, 1.6 +/- 0.2, or 1.7 +/- 0.1, 1.6 +/- 0.2, and 1.4 +/- 0.2 ms.kPa-1, respectively) compared with before medication (P < 0.01). m-Nis may act directly on carotid sinus to depress the BRS, but not through cardiac beta or M receptor nor through central nervous system.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6472}
}