TY - JOUR AU - Jia Min-jiang AU - Chen Shi-liang AU - Liao Yu-lin AU - Liu De-qiang AU - Li Lan-sun AU - Zhao Nan-ping PY - 2016 TI - Effects of furyl-dihydropyridine I on coronary collateral circulation in myocardial infarction of dogs JF - Acta Pharmacologica Sinica; Vol 15, No 5 (September 1994): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Effects of furyl-dihydropyridine I (FDP-1) on collateral circulation were observed in ischemic myocardium of dogs. FDP-1 (200 micrograms.kg-1) of intracoronary injection increased collateral flow, reduced systemic artery resistance, and coronary systolic pressure in infarcted region and the area of infarction decreased from 28.9 +/- 1.3% to 15.3 +/- 1.2% (P < 0.01, n = 6). The results indicated that FDP-1 could improve coronary collateral circulation, increase collateral flow in ischemic region, decrease collateral flow in ischemic region, decrease myocardial oxygen demand, and protect myocardial ischemia. UR - http://www.chinaphar.com/article/view/6470