@article{APS6452,
author = {Zhen-Lin Hu and Jun-Ping Zhang and Ding-Hua Qian and Wen Lin and Wei-Fen Xie and Xing-Rong Zhang and Wei-Zhong Chen},
title = {Effects of matrine on mouse splenocyte proliferation and release of interleukin-1 and -6 from peritoneal macrophages in vitro},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM: To investigate the mechanisms of anti-inflammatory effect of matrine (Mat), its effects on mouse splenocyte proliferation, and release of interleukin-1 (IL-1) and interleukin-6 (IL-6) from mouse peritoneal macrophages.
METHODS: Splenocyte proliferation was assayed by [3H] TdR incorporation. IL-1 and IL-6 activities were measured by thymocyte proliferation assay and B9 cell proliferation MTT colorimetric method, respectively.
RESULTS: Mat (125-500 mg.L-1) obviously inhibited concanavalin A (Con A, 5 mg.L-1)- and lipopolysaccarides (LPS, 10 mg.L-1)-induced splenocyte proliferation and LPS-induced release of IL-1 and IL-6 from mouse peritoneal macrophages.
CONCLUSION: Mat inhibited splenocyte proliferation and release of IL-1 and IL-6 in vitro.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6452}
}