%0 Journal Article %T Protective effects of 17 beta-estradiol on endothelial function injured by oxidized low-density lipoproteins %A Peng Chang-Fu %A Li Yuan-Jian %A Deng Han-Wu %A Xiong Xiao-Ming %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Protective effects of 17 beta-estradiol on endothelial function injured by oxidized low-density lipoproteins %K %X AIM: To test the protective effects of 17 beta-estradiol against endothelial cell damages due to oxidized low-density lipoproteins (LDL) and lysophosphatidylcholine (LPC), a principal component of oxidized LDL. METHODS: After the tension was increased by phenylephrine, the effects of oxidized LDL or LPC on the vasorelaxation responses to acetylcholine (ACh) were investigated in the isolated rabbit thoracic aortas. RESULTS: 17 beta-Estradiol attenuated the inhibition of vasorelaxation responses to ACh by oxidized LDL or LPC in a concentration-dependent manner. However, the protective effect of 17 beta-estradiol was partially attenuated by indometacin (10 mumol.L-1), a cyclooxygenase inhibitor. CONCLUSION: 17 beta-Estradiol possesses protective effects on the endothelium against injury elicited by oxidized LDL or LPC, which may be related to its stimulation of epoprostenol production. %U http://www.chinaphar.com/article/view/6448 %V 17 %N 3 %P 252-255 %@ 1745-7254