@article{APS6448,
author = {Chang-Fu Peng and Yuan-Jian Li and Han-Wu Deng and Xiao-Ming Xiong},
title = {Protective effects of 17 beta-estradiol on endothelial function injured by oxidized low-density lipoproteins},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM: To test the protective effects of 17 beta-estradiol against endothelial cell damages due to oxidized low-density lipoproteins (LDL) and lysophosphatidylcholine (LPC), a principal component of oxidized LDL.
METHODS: After the tension was increased by phenylephrine, the effects of oxidized LDL or LPC on the vasorelaxation responses to acetylcholine (ACh) were investigated in the isolated rabbit thoracic aortas.
RESULTS: 17 beta-Estradiol attenuated the inhibition of vasorelaxation responses to ACh by oxidized LDL or LPC in a concentration-dependent manner. However, the protective effect of 17 beta-estradiol was partially attenuated by indometacin (10 mumol.L-1), a cyclooxygenase inhibitor.
CONCLUSION: 17 beta-Estradiol possesses protective effects on the endothelium against injury elicited by oxidized LDL or LPC, which may be related to its stimulation of epoprostenol production.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6448}
}