%0 Journal Article %T Inhibition of [methyl-3H]diazepam binding to rat brain membranes in vitro by dinatin and skrofulein %A Shen Xing-liang %A Nielsen Mogens %A Witt Michael Robin %A Sterner Olov %A Bergendorff Ola %A Khayyal Mohamed %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Inhibition of [methyl-3H]diazepam binding to rat brain membranes in vitro by dinatin and skrofulein %K %X Two flavones, 4',5,7-trihydroxy-6-methoxy flavone (dinatin) and 4',5-dihydroxy-6, 7-dimethoxy flavone (skrofulein), were extracted from Artemisia herba alba L. Dinatin and skrofulein inhibited the binding of [methyl-3H]diazepam to rat brain membranes in vitro with IC50 of 1.3 and 23 mumol.L-1, respectively. The GABA-ratios (the ratio of IC50 values in the absence/presence of GABA in the binding assay) were 1.1 and 1.2 for dinatin and skrofulein, respectively. Both flavones induced a slight increase in [35S] TBPS binding. The data suggest that the flavones are antagonists or partial agonists of benzodiazepine receptors. %U http://www.chinaphar.com/article/view/6424 %V 15 %N 5 %P 385-388 %@ 1745-7254