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Inhibition of [methyl-3H]diazepam binding to rat brain membranes in vitro by dinatin and skrofulein

   
@article{APS6424,
	author = {Xing-liang Shen and Mogens Nielsen and Michael Robin Witt and Olov Sterner and Ola Bergendorff and Mohamed Khayyal},
	title = {Inhibition of [methyl-3H]diazepam binding to rat brain membranes in vitro by dinatin and skrofulein},
	journal = {Acta Pharmacologica Sinica},
	volume = {15},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {Two flavones, 4',5,7-trihydroxy-6-methoxy flavone (dinatin) and 4',5-dihydroxy-6, 7-dimethoxy flavone (skrofulein), were extracted from Artemisia herba alba L. Dinatin and skrofulein inhibited the binding of [methyl-3H]diazepam to rat brain membranes in vitro with IC50 of 1.3 and 23 mumol.L-1, respectively. The GABA-ratios (the ratio of IC50 values in the absence/presence of GABA in the binding assay) were 1.1 and 1.2 for dinatin and skrofulein, respectively. Both flavones induced a slight increase in [35S] TBPS binding. The data suggest that the flavones are antagonists or partial agonists of benzodiazepine receptors.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6424}
}