@article{APS6416,
author = {Jun Wang and Lu Zhang and Jian-Hua Qi and Pei-Jin Zhang and Pei-Jing Wei and Pei-Kun Gu and Zheng-Jun Jin},
title = {Effects of captopril and enalaprilat on intracellular Ca 2+ content in isolated cardiomyocytes from rats},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM: To study the effects of ACEI captopril (Cap) and enalaprilat (Ena) on intracellular Ca2+ concentration ([Ca2+]i) in cardiac myocytes isolated from SHR and WKY rats.
METHODS: Using fluorescent probe Fura 2-AM combined with computer image processing technique to measure [Ca2+]i.
RESULTS: Resting [Ca2+]i was higher in SHR cardiac myocytes (174 +/- 5 nmol.L-1) than that in WKY rat myocytes (148 +/- 15 nmol.L-1, P < 0.01). Cap and Ena decreased the resting [Ca2+]i in SHR myocytes (161 +/- 11 and 166 +/- 7 nmol.L-1, respectively, P < 0.05) but not in WKY rat myocytes (P > 0.05). Both drugs inhibited [Ca2+]i increment induced by KCI, NE, or Ang II in SHR and WKY rat myocytes except on KCI-induced [Ca2+]i increment in WKY rat myocytes (P > 0.05).
CONCLUSION: Cap and Ena had direct effects on pathological voltage-operated calcium channel in cardiac myocytes.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6416}
}