@article{APS6411,
author = {Gang-Gang Shi and Dong-Sheng Wei and Bao-Jiang Liu and Shao-Fen Xu},
title = {Effect of phencyclidine on dog coronary artery},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM: To study the effect of phencyclidine (Phe) on dog coronary artery.
METHODS: Contraction of spiral strips of dog coronary artery in bioassay and coronary artery blood flow (CBF) using electromagnetic flowmeter on anesthetized dogs were observed.
RESULTS: Phe 0.1-100 mumol.L-1 induced contraction of strips in a concentration-dependent manner. Dextromethorphan (Dex) 10 mumol.L-1, an antagonist of Phe receptor, antagonized the action of Phe. In vivo, Phe 10 mg.kg-1 increased flow of left circumflex coronary artery of anesthetized dogs from 334 +/- 35 mL.kg-1.min-1 to 510 +/- 58 mL.kg-1.min-1, and both left ventrical pressure (LVP) and blood pressure (BP) rose slowly after medication. Dextromethorphan (Dex) 5 mg.kg-1 also antagonized the effect of Phe.
CONCLUSION: The regulation of Phe on coronary artery in vivo differs from that in vitro, which may result in the contradictory effects.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6411}
}