@article{APS6408,
author = {Xiao-Ping Zhao and Shao Wang and Ying-Hong Xia},
title = {Effects of calcitonin injected into various brain areas on pain threshold and Ca 2+ in rats},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM: To study the effects of calcitonin (Cal) injected into different brain areas on pain threshold.
METHODS: The analgesic effects of Cal were investigated in rats by the tail-flick test.
RESULTS: Cal injected into lateral cerebral ventricle (LCV) or periaqueductal gray (PAG) increased obviously the pain threshold to 49 +/- 22% or to 68 +/- 12% (P < 0.01), respectively. When PAG was blocked with lidocaine, the analgesic effect of Cal injected into LCV was lowered 41 +/- 9%. Cal injected into habenula (Hab) decreased the pain threshold to -30 +/- 5% (P < 0.01).
CONCLUSIONS: Cal in different rat brain areas induced different effects on pain responses: analgesia or hyperalgesia, and showed that PAG played an important role in the analgesic effect induced by Cal, and the changing of pain threshold was mediated by the Ca2+ in brain.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6408}
}