TY - JOUR AU - Triggle David J. PY - 2016 TI - Depolarization as a regulatory signal at voltage-gated calcium channels. JF - Acta Pharmacologica Sinica; Vol 17, No 3 (May 1996): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Changes in membrane potential are a regulatory signal for voltage-gated ion channels including the family of Ca2+ channels. This regulatory role includes the voltage-dependent opening, closing, and inactivation of ion channels and the control of drug access and affinity for discrete channels states. Membrane potential is both a short- and long-term regulatory signal controlling the number and function of these voltage-gated channels. Depolarization of neuronal and neurosecretory cells produces down-regulation of L-type voltage-gated Ca2+ channels. These processes are described and their relevance to physiologic and pathologic processes of neuronal development and neuroprotection are indicated. UR - http://www.chinaphar.com/article/view/6399