TY - JOUR AU - Chen Li-Juan AU - Xi Yong AU - Pang Da-Wei AU - Zhou Qi-Ting AU - Jin Guo-Zhang PY - 2016 TI - Effect of (+/-)12-chloroscoulerine on brain dopamine receptors JF - Acta Pharmacologica Sinica; Vol 17, No 2 (March 1996): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - "AIM: To assess potencies of tetrahydroprotoberberines (THPB) and hydrobenzyltetrahydroisoquinolines (HBTI) on DA receptors. METHODS: The receptor binding assay with calf striatum to D1 and D2 receptors, and the animal behavior tests were used. RESULTS: (+/-) 12-Chloroscoulerine (CSL) was the most potent one among the THPB and HBTI. The affinities of CSL to D1 and D2 receptors were 13 and 51 nmol.L-1, respectively. In rats, CSL showed an antagonistic effect on the stereotypy and induced catalepsy. In the 6-OHDA lesioned rats, however, CSL exerted the agonistic effect to DA receptors. CONCLUSION: CSL had dual actions to DA receptors and its effects were similar to that of (-)stepholidine. " UR - http://www.chinaphar.com/article/view/6395