%0 Journal Article %T Effect of (+/-)12-chloroscoulerine on brain dopamine receptors %A Chen Li-Juan %A Xi Yong %A Pang Da-Wei %A Zhou Qi-Ting %A Jin Guo-Zhang %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Effect of (+/-)12-chloroscoulerine on brain dopamine receptors %K %X "AIM: To assess potencies of tetrahydroprotoberberines (THPB) and hydrobenzyltetrahydroisoquinolines (HBTI) on DA receptors. METHODS: The receptor binding assay with calf striatum to D1 and D2 receptors, and the animal behavior tests were used. RESULTS: (+/-) 12-Chloroscoulerine (CSL) was the most potent one among the THPB and HBTI. The affinities of CSL to D1 and D2 receptors were 13 and 51 nmol.L-1, respectively. In rats, CSL showed an antagonistic effect on the stereotypy and induced catalepsy. In the 6-OHDA lesioned rats, however, CSL exerted the agonistic effect to DA receptors. CONCLUSION: CSL had dual actions to DA receptors and its effects were similar to that of (-)stepholidine. " %U http://www.chinaphar.com/article/view/6395 %V 17 %N 2 %P 185-189 %@ 1745-7254