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Effect of (+/-)12-chloroscoulerine on brain dopamine receptors

	author = {Li-Juan Chen and Yong Xi and Da-Wei Pang and Qi-Ting Zhou and Guo-Zhang Jin},
	title = {Effect of (+/-)12-chloroscoulerine on brain dopamine receptors},
	journal = {Acta Pharmacologica Sinica},
	volume = {17},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {\"AIM: 

To assess potencies of tetrahydroprotoberberines (THPB) and hydrobenzyltetrahydroisoquinolines (HBTI) on DA receptors.


The receptor binding assay with calf striatum to D1 and D2 receptors, and the animal behavior tests were used.


(+/-) 12-Chloroscoulerine (CSL) was the most potent one among the THPB and HBTI. The affinities of CSL to D1 and D2 receptors were 13 and 51 nmol.L-1, respectively. In rats, CSL showed an antagonistic effect on the stereotypy and induced catalepsy. In the 6-OHDA lesioned rats, however, CSL exerted the agonistic effect to DA receptors.


CSL had dual actions to DA receptors and its effects were similar to that of (-)stepholidine.
	issn = {1745-7254},	url = {}