@article{APS6369,
author = {Xue Zhao and Wei-jun Fu and Wen-jun Yuan and Gang-xing Hou and Jian-guo Chen and Jing-hui Xia and He-nian Zhu},
title = {Influence of endothelin-1 on ventricular fibrillation threshold in acute myocardial ischemic rats},
journal = {Acta Pharmacologica Sinica},
volume = {15},
number = {4},
year = {2016},
keywords = {},
abstract = {The influence of endothelin-1 on ventricular fibrillation threshold was studied in acute myocardial ischemic rats. Endothelin-1 (1.5-3.0 micrograms.kg-1 i.v.) given 5 min before ischemia reduced the ventricular fibrillation threshold in a dose- and time-dependent manner. Its effect lasted at least 60 min. A marked increase of spontaneous ventricular tachycardia and myocardial infarct size was seen and the arterial blood pressure was at a higher level (18.5-20.1/14.4-15.8 kPa) after 3.0 micrograms.kg-1. Diltiazem prevented partially from reduction of ventricular fibrillation threshold, eliminated completely the vasopressor response and limited the extension of myocardial necrosis induced by endothelin-1.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6369}
}