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Mechanism of scavenging effects of (-)-epigallocatechin gallate on active oxygen free radicals

   
@article{APS6366,
	author = {Xian-qiang Yang and Sheng-rong Shen and Jing-wu Hou and Bao-lu Zhao and Wen-juan Xin},
	title = {Mechanism of scavenging effects of (-)-epigallocatechin gallate on active oxygen free radicals},
	journal = {Acta Pharmacologica Sinica},
	volume = {15},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {The concentration of 50% scavenging ratio (SC50) and the scavenging rate constants (k) and stiochiometric factor (n) were determined when (-)-epigallocatechin gallate [(-)-EGCG] scavenging superoxide anion free radical (O2.-) and hydroxyl radical (.OH). The mechanism of scavenging active free radicals of (-)-EGCG and the promotion of (-)-EGCG free radical and its structure were analyzed in vitro. Our results suggest that the centers of scavenging reaction of (-)-EGCG are B, D, and A cycles, and each (-)-EGCG traps six O2.- or .OH. It is in accord with the value of stiochiometric factor n = 6.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6366}
}