TY  - JOUR
AU  - Wu Jie
AU  - Yu Xiao-jiang
AU  - Ma Xin
AU  - Li Xiao-guang
AU  - Liu Dong
PY  - 2016
TI  - Electrophysiologic effects of total flavones of Hippophae rhamnoides L on guinea pig papillary muscles and cultured rat myocardial cells
JF  - Acta Pharmacologica Sinica; Vol 15, No 4 (July 1994): Acta Pharmacologica Sinica
Y2  - 2016
KW  - 
N2  - The effects of total flavones of Hippophae rhamnoides L (TFH) were evaluated using conventional microelectrode technic. After administration of TFH 100-200 mg.L-1, the action potential duration of 50% repolarization (APD50) was shortened both in cultured rat myocardial cells and in guinea pig papillary muscles. The slope of phase 4 of depolarization (SP4) in cultured rat myocardial cells was decreased and the contractile force (CF) in guinea pig papillary muscles was weakened. Arrhythmias evoked by strophantin G in guinea pig papillary muscles were suppressed by TFH 100 mg.L-1. These findings suggested that the influence of TFH on myocardial cells may be resulted mainly from its inhibition of Ca2+ influx and its interference with intracellular Ca2+ reservoir.
UR  - http://www.chinaphar.com/article/view/6363