%0 Journal Article
%T Effect of TGF-β1 antisense oligodeoxynucleotide on renal function in chronic renal failure rats
%A Hiong Law Chung
%A Voon Kiew Lik
%A Abdullah Nor Azizan
%A Sattar Munavvar A
%A Rahman Nazarina Abdul
%A Khan Abdul Hye
%A Johns Edward James
%J Acta Pharmacologica Sinica
%D 2016
%B 2016
%9 
%! Effect of TGF-β1 antisense oligodeoxynucleotide on renal function in chronic renal failure rats
%K 
%X Aim:  The aim of the present study was to investigate the effectiveness of transforming growth factor (TGF)-β1 antisense oligodeoxynucleotides (ODN) in ameliorating deteriorated kidney function in rats with puromycin-induced chronic renal failure (CRF).  Methods:  Saline, puromycin, puromycin+TGF-β1 antisense ODN or puromycin+scrambled ODN were administered to unilaterally nephrectomized rats. Renal hemodynamic and excretory measurements were taken in the anaesthetized rats that had undergone surgical procedure.  Results:  It was observed that in the CRF rats, there was a marked reduction in the renal blood flow (RBF), glomerular filtration rate (GFR), severe proteinuria, and almost 6-fold increased fractional excretion of sodium (FE Na+) as compared to that in the control rats (all P
%U http://www.chinaphar.com/article/view/6325
%V 29
%N 4
%P 451–457
%@ 1745-7254