TY - JOUR AU - Fan Li-hong AU - Tian Hong-yan AU - Ma Ai-qun AU - Hu Zhi AU - Huo Jian-hua AU - Cao Yong-xiao PY - 2016 TI - Altered ATP-sensitive potassium channels may underscore obesity-triggered increase in blood pressure JF - Acta Pharmacologica Sinica; Vol 29, No 10 (October 2008): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Aim: To determine whether ATP-sensitive potassium channels are altered in VSMC from arotas and mesenteric arteries of obese rat, and their association with obesity-triggered increase in blood pressure. Methods: Obesity was induced by 24 weeks of high-fat diet feeding in male Sprague-Dawley rats. Control rats were fed with standard laboratory rat chow. Blood pressure and body weight of these rats were measured every 4 weeks. At the end of 24 weeks, K ATP channel-mediated relaxation responses in the aortas and mesenteric arteries, K ATP channel current, and gene expression were examined, respectively. Results: Blood pressure and body weight were increased in rats fed with high-fat diet. K ATP channel-mediated relaxation responses, currents, and K ATP expression in VSMC of both aortas and mesenteric arteries were inhibited in these rats. Conclusion: Altered ATP-sensitive potassium channels in obese rats may underscore obesity-triggered increase in blood pressure. UR - http://www.chinaphar.com/article/view/6319