@article{APS6316,
author = {Zhen Li and Gang Chen},
title = {Evaluation of theophylline population pharmacokinetics in adult hospitalized patients using NONMEM analysis},
journal = {Acta Pharmacologica Sinica},
volume = {15},
number = {3},
year = {2016},
keywords = {},
abstract = {The population pharmacokinetics of theophylline was evaluated using 374 theophylline serum concentration measurements from 72 hospitalized patients through NONMEM analysis. An one-compartment open pharmacokinetic model with first-order absorption and first-order elimination was used. The effects of a variety of factors on Cl and Vd were investigated. Hypothesis testing to evaluated potentially significant factors produced a final regression model. There were about 1.25% per year decrease in Cl at the age of 18-77. Cl was reduced by 26.8% for patients with long history of theophylline administration and multiple dosings, and reduced by 33.9% in OLD patients. Sex, body weight, and coadministration of acetylspiramycin had no significant effects on Cl. Vd was proportional to body weight. The final regression model allowed a priori estimate of the theophylline pharmacokinetic parameters in the patients. These results may be helpful to a rational individualized theophylline dosage regimen.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6316}
}