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Effects of spermine on phosphorylation of phosphoinositide and 47 K protein in platelet membranes of pig

  
@article{APS6277,
	author = {Ke-Hong Ding and Nian-Ci Liang},
	title = {Effects of spermine on phosphorylation of phosphoinositide and 47 K protein in platelet membranes of pig},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {In the presence of Mg2+ and exogenous phosphatidylinositol-4-phosphate, swine thrombocytic membranes were incubated with [gamma-32P]ATP at 30 degrees C for 3 min and the incorporations of 32P into phospholipids and proteins were measured. Spermine stimulated the formation of phosphatidylinositol-4,5-bisphosphate (optimal concentration 0.25 mmol.L-1) and inhibited the phosphorylation of 47 K protein (IC50 1 mmol.L-1). This helps to clarify the effect of spermine on cell growth and proliferation.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6277}
}