%0 Journal Article
%T Antitumor effects of new-type recombinant interleukin-2
%A Feng Xue-Sheng
%A Zheng Xiu-Juan
%A Si Qiu-Sheng
%A Lin Yun-Lu
%A Chang Yuan
%A Fan Pei-Fang
%A Yu Jian-Liang
%A Zhang Shu-Ren
%A Liu Xin-Yuan
%J Acta Pharmacologica Sinica
%D 2016
%B 2016
%9 
%! Antitumor effects of new-type recombinant interleukin-2
%K 
%X Two new human recombinant interleukin-2 (rIL-2), 125-Ser-rIL-2, and 125-Ala-rIL-2, were generated by protein engineering technique. Both of them maintained the proliferation of natural killer (NK) cells, CTLL-2 cells and their long-term propagations. The mutated new rIL-2 also enhanced the bioactivity of NK cells and the cytotoxicity of tumor-infiltrating lymphocytes (TIL) against the target tumor cells. The above results were all compared with that of the native rIL-2 and a similarity between them was found, which indicates that new type rIL-2 could be used for adoptive immunotherapy of malignant diseases.
%U http://www.chinaphar.com/article/view/6272
%V 13
%N 5
%P 435-438
%@ 1745-7254