%0 Journal Article %T Toxicity to transferred rat embryos after aspirin treatment during preimplantation stage in vivo. %A Lou Yi-Jia %A Ding Guang-Sheng %A Tu Zeng-Hong %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Toxicity to transferred rat embryos after aspirin treatment during preimplantation stage in vivo. %K %X "AIM: To explore the relationship between drug-induced blastopathies and post-implantation embryotoxicity or developmental defects. METHODS: Pregnant rats on d 3 were given intragastrically aspirin (0.25, 0.5, and 1 g.kg-1). On d 4, the blastocysts were transferred into the uterine horns of pseudopregnant rats (made by mating with male rats which had been given intragastrically 3-chloro-1,2-propanediol 5 mg.kg-1 for 5 d). Uterine contents were examined at term. RESULTS: The frequency of blastocysts with morphological alterations (FBMA) was increased on d 4 of gestation. The implantation rate was lower than that of the controls. A dose-related increase in resorption (55.2%, 69.5%, and 85.2%) and malformation rate (3.8%, 44.4%, and 25%), and decrease in viability rate of fetuses (44.8%, 30.5%, and 14.8%) were observed in test groups with correlations to FBMA. CONCLUSION: Embryotoxicity and fetal malformations were induced by treatment of aspirin before implantation in a dose-dependent manner. " %U http://www.chinaphar.com/article/view/6252 %V 17 %N 1 %P 52-54 %@ 1745-7254