%0 Journal Article %T Cardiovascular effects of injection of argipressin into lateral septal nuclei in rats. %A Gao Lie %A Jiang Nai-Chang %A Luo Qing-Hua %A Zhu Zhu-Xia %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Cardiovascular effects of injection of argipressin into lateral septal nuclei in rats. %K %X "AIM: To determine whether argipressin (Arg) plays a role in central neural control of cardiovascular function by acting on the lateral septal nuclei (LSN). METHODS: Measuring mean arterial blood pressure (MAP) and heart rate (HR) responses followed microinjection of Arg into the LSN of rats anesthetized with urethane. RESULTS: Arg (100, 200, and 400 ng) injected into the LSN produced a dose-dependent hypertension and tachycardia. Maximal changes of MAP were 0.9 +/- 0.6, 2.3 +/- 1.3, 4.0 +/- 1.4 kPa, respectively; maximal changes of HR were 12 +/- 27, 50 +/- 33, and 89 +/- 27 bpm, respectively. Pretreatment of the LSN with a vasopressin 1 type antagonist d (CH2)5Tyr(Me) Arg abolished the MAP and HR responses produced by injection of Arg. Peripheral alpha-adrenergic blockade with phentolamine blocked the hypertension responses to injection of Arg into the LSN. CONCLUSION: Arg acts in the region of the LSN to exert a central action on the cardiovascular system that is mediates by stimulation of sympathetic outflow. " %U http://www.chinaphar.com/article/view/6251 %V 17 %N 1 %P 49-52 %@ 1745-7254