TY - JOUR AU - Wang You-Lin AU - Tang Guo-Zhi AU - Ding Jian-Hua AU - Li De-Xing PY - 2016 TI - Effects of nitrendipine on capacity of calcium binding of erythrocyte membrane and total intraerythrocyte calcium content in SHR rats. JF - Acta Pharmacologica Sinica; Vol 17, No 1 (January 1996): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - "AIM: To study the effect of nitrendipine (Nit) on the capacity of calcium binding of erythrocyte membrane and total intraerythrocyte calcium content in spontaneous hypertensive rats (SHR). METHODS: Systolic blood pressure (SBP) of the conscious rats was monitored by tailcuff method with a BP and HR recorder for MRS-III rat. Erythrocyte membrane was prepared according to modified Bing's method. Calcium binding of membrane and total intraerythrocyte calcium content was determined by an automatic absorption spectrophotometer. The membrane protein was determined with a colorimetric method. RESULTS: Nit (ig 10 mg.kg-1 qd x 20 d) induced a significant reduction in total intraerythrocyte calcium content (169 +/- 18 vs 87 +/- 14 mumol/L cell, P 0.05). CONCLUSION: The antihypertensive effect of Nit is related to the reduction of intracellular calcium and possibly have no direct relation to the capacity of calcium binding of cell membrane. " UR - http://www.chinaphar.com/article/view/6248