TY - JOUR AU - Fang Ji-Qian AU - Ni Tao-Yang AU - Fu Cheng-Zhu AU - Fan Qing AU - Guan Yong-Yuan PY - 2016 TI - Two-state stochastic models for memory in ion channels JF - Acta Pharmacologica Sinica; Vol 17, No 1 (January 1996): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - AIM: To study quantitatively the memory existing in ion channels. METHODS: Stochastic processes were used to model 2 categories of memory (short-term and long-term) by persisting in the standpoint of two-state, instead of multiple states, but with different transition mechanism. RESULTS: A two-state Markov process with constant transition intensities well fitted the short-term memory and a two-state Markov process within a kind of random environment well fitted the long-term memory. Statistical procedures for parameter estimation were proposed and demonstrated with 2 real examples on the channels of PC12 cells. CONCLUSION: The memory in ion channels can be quantitatively modelled as stochastic process with 2 states. UR - http://www.chinaphar.com/article/view/6242