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Evaluation of the tissue-to-blood partition coefficient R for physiological pharmacokinetic models

   
@article{APS6228,
	author = {Yong Ding and Da-Kuang Huang and Jian-Ping Luo},
	title = {Evaluation of the tissue-to-blood partition coefficient R for physiological pharmacokinetic models},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {The tissue-to-blood partition coefficient R, fraction of drug unbound in blood fB and intrinsic clearance of elimination organ/tissue Cl'L are important parameters used in physiological pharmacokinetic models. Simple equations to evaluate R by AUC were derived in this paper for single bolus iv, the tissue-to-blood partition coefficient of nonelimination organ/tissue was exactly the ratio of AUC between tissue and blood, those equations were examined by the experimental data of rats following iv ethoxybenzamide 20 mg.kg-1, and compared with other methods. Equations to evaluate fBCl'L and other parameters were also given for linear elimination model.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6228}
}