TY  - JOUR
AU  - An Rui-Hai
AU  - Fan Zhen-Zhong
AU  - He Rui-Rong
PY  - 2016
TI  - Effects of m-nisoldipine on transmembrane currents of guinea pig papillary muscles
JF  - Acta Pharmacologica Sinica; Vol 13, No 4 (July 1992): Acta Pharmacologica Sinica
Y2  - 2016
KW  - 
N2  - Effects of m-Nis on the transmembrane currents were studied using single sucrose gap voltage clamp technique. The amplitude of slow inward current (I(si)) was 10.6 +/- 4.1 microA. Maximal inward current was induced at a membrane potential range between -20 to -25 mV. The amplitude of I(si) were significantly decreased by m-Nis (0.2 mumol.L-1) with a reduction of 47.3%. The transient inward current (I(ti)) induced by ouabain was also greatly depressed or prevented by m-Nis, resulting in the inhibition of DAD.
UR  - http://www.chinaphar.com/article/view/6227