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Effect of dizocilpine maleate on cerebral anoxia and ischemic damage in rodents

   
@article{APS6220,
	author = {Han-Xian Ping and Jin Su and Hui Liu and Guo-Qing Liu and Lin Xie and Hui-Qiu Wu},
	title = {Effect of dizocilpine maleate on cerebral anoxia and ischemic damage in rodents},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {The Protective effects of dizocilpine maleate (DM) against anoxia in mice and ischemic damage in rats of 4-vessel occlusion (4-VO) were studied. DM 0.5 or 1.0 mg.kg-1 ip significantly prolonged the survival time of mice in closed containers. DM 0.5 and 1.0 mg.kg-1 ip 30 min prior to 4-VO obviously accelerated the electroencephalographic recovery, reduced the neuronal loss in the hippocampus, and increased the survival rate after 72-h reperfusion. These effects followed a dose-dependent manner. Our results indicate that selective non-competitive N-methyl-D-aspartate receptor blocker DM protects against anoxic and ischemic cerebral damage.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6220}
}