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Effect of cholinesterase inhibition in vitro by huperzine analogs

   
@article{APS6211,
	author = {Xi-can Tang and Hong Xu and Jie Feng and Tian-xi Zhou and Jia-sen Liu},
	title = {Effect of cholinesterase inhibition in vitro by huperzine analogs},
	journal = {Acta Pharmacologica Sinica},
	volume = {15},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Huperzine (Hup) A and B were first discovered and studied by Chinese. Fourteen analogs of Hup were tested for their anticholinesterase (anti-ChE) activity by colorimetric method using rat erythrocyte membrane and serum as enzyme sources. Hup-A showed the highest anti-AChE potency. The anti-BuChE activity of (-)dihydro and (-)tetrahydro analogs were potent than those of Hup-A. Their anti-AChE activities were comparable to those of physostigmine and galanthamine. Dihydro analog inhibition was of the mixed competitive type with a Ki value of 0.12 mumol.L-1. Tetrahydro analog inhibition was of the competitive type with a Ki value of 0.56 mumol.L-1. They were different from isoflurophate to bond to AChE in a reversible manner},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6211}
}