@article{APS6200,
author = {Guo-gan ZHONG and Cheng-wen SUN and Yun-yi LI and Hui QI and Chun-yan ZHAO and Yan JIANG and Xiao-ming WANG and Shi-jie YANG and Hong LI},
title = {Calcium channel blockade and anti-free-radical actions of panaxadiol saponins Rb1, Rb2, Rb3, Rc, and Rd},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM: To identify the calcium channel blockade and anti-free-radical actions of panaxadiol saponins Rb1, Rb2, Rb3, Rc, and Rd.
METHODS: On ventricular myocardiocytes of Wistar rats, single channel activities of L, T, and B type Ca2+ channels were recorded with the cell-attached configuration of patch-clamp technic, and free radical contents were measured with electron spin resenance method.
RESULTS: Rb1, Rb2, Rb3, and Rc 200 mumol.L-1 shortened the open times, prolonged the close times, and reduced the openstate probabilities of calcium channels and 30 mumol.L-1 antagonized the increase of free radical content induced by xanthine 0.42 mmol.L-1-xanthine oxidase 5.3 nmol.L-1, but Rd in the same dose behaved none of the effects.
CONCLUSION: Rb1, Rb2, Rb3, and Rc had both the calcium channel blockade and anti-free-radical actions.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6200}
}