@article{APS6190,
author = {Bu-er Wang and Jie-shi Cheng},
title = {Alteration of dynorphin1-8 and leu-enkephalin in rat hippocampus during seizure and electroacupuncture},
journal = {Acta Pharmacologica Sinica},
volume = {15},
number = {2},
year = {2016},
keywords = {},
abstract = {Immunocytochemical technics were used to evaluate the influence of penicillin-induced seizure and electroacupuncture treatment on dynorphin1-8 and leu-enkephalin immunoreactivity in hippocampus. It was found that 3 h after beginning of seizure there started a dramatic decrease in dynorphin1-8 in hilus, mossy fiber of hippocampus but an increase in hilus, mossy fiber of hippocampus but an increase in leu-enkephalin in subiculum, CA1 area of hippocampus and some other limbic structures. Electroacupuncture treatment decreased the leu-enkephalin immunoreactivity in the nuclei mentioned above and increased dynorphin1-8 immunoreactivity in hippocampus. The results show that epileptiform activity and electroacupuncture inhibitory effect on seizure may be related to the alteration of dynorphin1-8 and leu-enkephalin in the brain.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6190}
}