@article{APS6189,
author = {Ke-jian ZHANG and Tong-jun LIN and Ling QIN and Geng-tao LIU},
title = {Effect of schisanhenol on function and surface shape of rat neutrophils},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM: To study the regulatory effect of Schisanhenol (Sal) on function of rat neutrophils.
RESULTS: It was found that Sal (1, 10, and 100 mumol.L(-1)) inhibited neutrophil activities such as chemotaxis, phagocytosis, and superoxide anion production in vitro in a concentration-dependent manner. Changes of surface morphology of neutrophils were observed by scanning electron microscopy, showing that the ruffles and pseudopods on neutrophil surface increased under the stimulation by chemotactic peptide N-formyl-Met-Leu-Phe (FMLP). When pretreated with Sal 100 mumol.L(-1), the ruffles and pseudopods disappeared and the surface became smooth. Sal 100 mumol.L(-1) decreased the cytosolic calcium concentration of neutrophils and increased the intracellular cAMP level.
CONCLUSION: These data suggested that Sal could inhibit the function of rat neutrophils through affecting the cytosolic free calcium and cAMP level besides its anti-oxidant activity.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6189}
}