@article{APS6183,
author = {Dong XIAO and Zhen-lun GU and Jian-ping BAI and Zhong WANG},
title = {Effects of quercetin on aggregation and intracellular free calcium of platelets},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM: To study the effects of Que on the intraplatelet free calcium concentration and the effects of calcium on the inhibition of platelet aggregation by Que.
METHODS: Using Quin-2 fluorescence technique.
RESULTS: Que inhibited the platelet aggregation and the rise of [Ca2+]i induced by thrombin in platelets. The values of IC50 and 95% confidence interval were 146.2 (92.4 - 231.3) and 78.5 (49.5 - 124.4) mumol.L-1, respectively. The inhibitory effects of Que on platelet aggregation induced by thrombin were reduced by adding calcium to the medium, and Que had no effect on thrombin-induced internal Ca2+ release from dense tubular system.
CONCLUSION: The inhibitory effects of Que on aggregation and the rise of [Ca2+]i in platelets was mainly due to an inhibition of Ca2+ influx.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6183}
}