@article{APS6179,
author = {Bo Xuan and Wei Wang and De-xin Li},
title = {Inhibitory effect of tetrahydroberberine on platelet aggregation and thrombosis},
journal = {Acta Pharmacologica Sinica},
volume = {15},
number = {2},
year = {2016},
keywords = {},
abstract = {Tetrahydroberberine (THB), an alkaloid extracted from Corydalis ambigua, inhibited the rabbit platelet aggregation triggered by arachidonic acid (AA), ADP, and collagen with IC50 of 0.86, 1.31, and 1.10 mmol.L-1, respectively. THB reduced the thromboxane B2 (TXB2) generation in rabbit platelet-rich plasma triggered by AA. THB 30 mg.kg-1.d-1 ip for 3 or 5 d restrained the ADP-induced platelet aggregation in rats. THB 30 mg.kg-1.d-1 ip for 1, 3, or 5 d inhibited the AA-induced platelet aggregation in rats. THB 15-30 mg.kg-1 iv showed an inhibition of venous thrombosis in rats. The results show that THB is a potent inhibitor of platelet aggregation in vitro and in vivo and is a promising antithrombotic drug.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6179}
}