@article{APS6160,
author = {Jian-Min Xiong and Bin Liang and Yun-Qiang Mo and Zhi-He Chen},
title = {Teratologic studies of methyl 5-aminosalicylate and salicylazopyridine},
journal = {Acta Pharmacologica Sinica},
volume = {13},
number = {3},
year = {2016},
keywords = {},
abstract = {Methyl 5-aminosalicylate hydrochloride (M-5-AS) at the dosages of 21, 42, 209, and 417 mg.kg-1.d-1 ig to mice during d 6-15 of pregnancy, no obvious effects on the placenta, fetus weight, sex differentiation, external appearance, visceral, and skeletal development were observed. In rats ig M-5-AS 56 and 556 mg.kg-1.d-1 produced no noticeable effects on the organogenesis or teratogenesis either. In mice and rats ig salicylazopyridine 410 and 1089 mg.kg-1.d-1 respectively no obvious teratogenicity was detected. However, aspirin 250 mg.kg-1.d-1 ig did bring about significant teratogenicity in rats.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6160}
}