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Inhibitory effects of tetrandrine on Bay k 8644-stimulated contraction of isolated rabbit aortic strips

  
@article{APS6151,
	author = {Yue-Ming Qian and Yue-Hua Huang},
	title = {Inhibitory effects of tetrandrine on Bay k 8644-stimulated contraction of isolated rabbit aortic strips},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {In the presence of KCl 19 mmol.L-1, calcium agonist Bay k 8644 0.47 mumol.L-1 elicited a strong contraction of isolated rabbit aortic strips, and this contraction was concentration-dependently inhibited by tetrandrine; but this antagonism was noncompetitive. Calcium ionophore calcimycin evoked contraction was markedly depressed by tetrandrine. The results suggested that tetrandrine might not only inhibit transmembrane influx of calcium via potential-dependent channels but also interfere with other processes related to calcium.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6151}
}