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Effect of new-breviscapine on fibrinolysis and anticoagulation of human vascular endothelial cells

   
@article{APS6150,
	author = {Quan-Sheng Zhou and Yi-Ming Zhao and Xia Bai and Pei-Xia Li and Chang-Geng Ruan},
	title = {Effect of new-breviscapine on fibrinolysis and anticoagulation of human vascular endothelial cells},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {Cultured confluent human umbilical vein endothelial cells were incubated with new-breviscapine (NB), a flavonoid consisting of 4-OH-scutellarin-7-O-glucuronide (C33H30O18) and FeCl3, MgCl2, and CaCl2, which is first extracted from Erigeron breviscapus (Vant) Hand-Mazz in China, 0, 6.25, 12.5, 25, 50, 100, and 1,000 micrograms.ml-1. The releases of tissue-type plasminogen activator (t-PA), and epoprostenol (Epo) from endothelial cells were stimulated by NB, but no significant effect of plasminogen activator inhibitor (PAI) activity was seen. NB 25-1,000 micrograms.ml-1 induced a production of thrombomodulin (TM) within the cells, an expression of TM on the surface of the cells, and a release of TM from the cells. Our data provide a new evidence that NB is a stimulant to fibrinolysis and anticoagulation of endothelial cells.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6150}
}