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Effect of dizocilpine maleate on monoamines and their metabolites in rat brain

   
@article{APS6128,
	author = {Han-Xian Ping and Lin Xie and Xuai-Jian Gong and Guo-Qing Liu and Hui-Qiu Wu},
	title = {Effect of dizocilpine maleate on monoamines and their metabolites in rat brain},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {Systemic (ip) injection of dizocilpine maleate (DM, 0.1 and 0.5 mg.kg-1) increased the levels of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid but did not bring about any noticeable change in the dopamine (DA) level in the striatum and limbic area. DM also increased the levels of norepinephrine in the limbic area and 5-hydroxyindoleacetic acid in the hippocampus. Amphetamine increased DA level and reduced DOPAC level in the striatum and limbic area. The behavioral manifestations revealed that DM predominantly evoked circling behavior and ataxia. The results indicate that the mechanism of the behavioral effect of DM may be different from that of amphetamine.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6128}
}