@article{APS6123,
author = {Yogeshi Dwivedi and Ravi Rastogi and Nnrendra Kumar Garg and Bhola Nath Dhawan},
title = {Effects of picroliv, the active principle of Picrorhiza kurroa, on biochemical changes in rat liver poisoned by Amanita phalloides},
journal = {Acta Pharmacologica Sinica},
volume = {13},
number = {3},
year = {2016},
keywords = {},
abstract = {The efficacy of Picroliv, a standardized iridoid glycoside fraction of Picrorhiza kurroa, was studied against the Amanita phalloides-induced biochemical changes in rat liver. A phalloides (50 mg.kg-1) caused significant increases in the activities of hepatic 5'-nucleotidase, gamma-glutamyl transpeptidase, acid ribonuclease, and succinate dehydrogenase, but a decrease in glucose-6-phosphatase. The level of cytochrome P-450 in microsomal fraction and content of glycogen in liver showed significant depletions. Picroliv (25 mg.kg-1.d-1 x 10 d) provided significant restorations of all the biochemical changes poisoned by A phalloides except cytochrome P-450 and glycogen. These results demonstrated the protective effect of Picroliv against A phalloides-induced hepatotoxicity in rats.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6123}
}