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Chronopharmacokinetics of valproic acid following constant-rate administration in mice and influence of feeding schedule

   
@article{APS6109,
	author = {Jian-guo SONG and Shigehiro OHDO and Nobuya OGAWA},
	title = {Chronopharmacokinetics of valproic acid following constant-rate administration in mice and influence of feeding schedule},
	journal = {Acta Pharmacologica Sinica},
	volume = {16},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the circadian rhythm in pharmacokinetics of valproic acid (VA) and influence of feeding schedule on the rhythm.
METHODS: Sodium valproate was administered by osmotic minipump technique (1.062 mg.h-1) and i.v. (50 mg.kg-1) to ICR mice fed under ad lib or time-restricted schedules to determine the time-dependent changes of VA kinetics.
RESULTS: Plasma VA concentration and clearance at steady-state showed circadian rhythms (P < 0.01). Time-restricted feeding influenced the rhythm of VA kinetics, acrophases of rhythms shifted approximately 12 h.
CONCLUSION: Timing of dosing is important for VA kinetics and feeding schedule is one of synchronizers in VA kinetics.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6109}
}