@article{APS6086,
author = {Ming-hui YAO and Ze-xiang DAI and Duan-zheng XU and Zao-chen YANG},
title = {Effects of nimodipine, felodipine, and verapamil on isolated human arteries},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {1},
year = {2016},
keywords = {},
abstract = {AIM: To evaluate whether there might be some difference in the action modes of nimodipine (Nim) and felodipine (Fel).
METHODS: Compare the inhibitory effects of Nim and Fel with that of verapamil (Ver) as a representative of phenylalklamine on norepinephrine (NE)- and CaCl2-evoked contractions of human arteries.
RESULTS: In Ca(2+)-free and high K+ depolarized solution, inhibitory effects of Nim, Fel, and Ver were more potent on CaCl2-induced contractions on isolated human arteries than those on NE-induced contractions. In CaCl2-induced contraction, the pD2 values for Nim, Fel, and Ver were 7.5, 7.42, 6.35 on uterine arteries; 7.38, 7.65, 7.20 on mesenteric arteries and 7.87, 9.10, 7.32 on renal arteries, respectively. Ver inhibited 2 components of NE-evoked contraction, while Nim and Fel only inhibited extracellular Ca(2+)-dependent contractions.
CONCLUSION: The result indicates that Fel has a selective action on human renal arteries.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6086}
}