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Pharmacokinetic analysis of enterohepatic circulation of piroxicam in rabbits

   
@article{APS6070,
	author = {Huai-Wu Zhou and Jia-Qing Shen and Ming Lu and Wen-Quan Liang and Wu Lin and Wei-Hong Zhao},
	title = {Pharmacokinetic analysis of enterohepatic circulation of piroxicam in rabbits},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {The concentration (c)-time (t) curves of piroxicam showed double peaks following iv 10 mg dose to 4 rabbits. A new mathematical model of enterohepatic circulation was proposed to explain this double-peak phenomenon and showed good agreement with data. This model provides not only the common pharmacokinetic parameters: T1/2 = 1.12 +/- 0.32 h, V1 = 0.64 +/- 0.12 L, AUC = 34.7 +/- 7.8 micrograms.h-1.ml-1, but also the parameters of enterohepatic circulation of piroxicam: the cycling amount of drug Db = 3.9 +/- 1.4 mg, reabsorption fraction Fb = 0.50 +/- 0.04, reabsorption rate constant Ka = 2.55 +/- 0.50 h-1. It is indicated in this study that enterohepatic circulation results in a 20% average increase of the effective amount of piroxicam.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6070}
}