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Effects of naphthylmethyl isoquinoline on contraction and calcium flux of rabbit vascular strips in vitro

   
@article{APS6069,
	author = {Wei-Zhong Zhu and Yu-Lin Yang},
	title = {Effects of naphthylmethyl isoquinoline on contraction and calcium flux of rabbit vascular strips in vitro},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Naphthylmethyl isoquinoline (NI) 1-30 mumol.L-1 inhibited the contraction of rabbit vascular smooth muscle in vitro induced by KCl, CaCl2, and norepinephrine (NE). NI 0.3-30 mumol.L-1 blocked 45Ca2+ influx process in vascular smooth muscle of aorta, mesenteric and femoral arteries by addition of KCl and NE. NI 3-10 mumol.L-1 had no effect on 45Ca2+ efflux from aorta at resting state. These results suggest that the relaxing effect of NI on rabbit blood vessels may be relevant to the inhibition of Ca2+ influx into vascular smooth muscle.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6069}
}