TY - JOUR AU - Yu Li-jian AU - Ma Run-di AU - Jiang Shi-bo PY - 2016 TI - Effects of tubeimoside-1 on HIV core protein p24 and cytopathogenesis in vitro JF - Acta Pharmacologica Sinica; Vol 15, No 2 (March 1994): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Tubeimoside-1 (Tub) is a triterpenoid saponin first isolated in China from Bolbostemma paniculatum (Maxim) Franquet, Cucurbitaceae. To find out whether Tub has any anti-infective activity on human immunodeficiency virus (HIV), we tested its effects on HIV core protein p24 (with an ELISA) and HIV-mediated cytopathogenesis (using a colorimetric assay). The results showed that Tub inhibited both p24 production and cytopathogenesis mediated by HTLV-IIIB, and the median effective concentrations (EC50) were 24.1 and 22.9 micrograms.ml-1, respectively. Tub also effectively neutralized the infection of 2 other isolates, HTLV-IIIRF and HTLV-IIIMN. It is concluded that Tub had an inhibitory action on the infection of HIV-1 isolates and would be a promising candidate for treatment of AIDS UR - http://www.chinaphar.com/article/view/6054